Additionally, pattern recognition receptors like TLR2 and TLR4 on microglia can be chronically stimulated or desensitized by repetitive exposure to microbial MAMPs translocating from the gut, potentially affecting how microglia respond to misfolded proteins (either by over-reacting and causing bystander damage, or by entering a tolerant state that might impair clearance of aggregates) [71, 119]
possible contribution to isotretinoin-associated mood changes Serotonin syndrome co-trigger / risk rises sharply when a third serotonergic agent (e.g., SSRI) is added Evidence level / preclinical and observational
Liu X, Zhao Y, Wu X, Liu Z, Liu X
While the primary action of BPC is in the digestive tract, where it heals and protects the GI lining, BPC-157 is linked in clinical studies to benefits in multiple organ systems
I was like, I realized that if you work really hard at something and you're completely obsessed with something, it could transform your life